Comfy as you may be, you may now notice that your feet have taken quite the beating, with the skin on the bottom looking rough, cracked, and. Hand and Foot Dermatitis - Etiology, pathophysiology, symptoms, signs, and appearance of the skin lesions (see table Differential Diagnosis of Hand Painless patchy peeling of the palms, soles, or both is characteristic of this disorder. The peeling of the skin at the bottom of the foot is caused by candida. That means that the body is full of sugar and parasites. Often people consume cow milk. Ongoing dryness and scaling on the soles and up the sides of your foot; Ulcers or sores that leak fluid, smell bad, and look red. Causes. The.