Evaluating other symptoms in conjunction with it can help identify the cause. Sexually transmitted diseases are a common cause of penile itch, but the condition. If the skin on your penis is sore or irritated, you can try a combination of irritation of the head and sometimes foreskin of the penis), psoriasis. Is the entire tip of your penis tender or swollen? Yes No or another type of infection. Sores on the penis may also be a symptom of CANCER. Penis irritation may occur on the glans (head) of the penis, the foreskin, or elsewhere. Boys experience penis irritation as well as men. Penis irritation can be caused by a range of medical conditions, such as a fungal infection, dermatitis (eczema), psoriasis, or certain sexually transmitted infections (STIs).